Appendix B: Phytonadione (Vitamin K) Dosing Guidelines INR > 9.0, No significant bleeding Repeat INR; hold warfarin. Monitor INR every 12-24 hours. Consider oral phytonadione at a dose of 2.5 to 5 mg (INR reduction expected to occur within 24 hours). Resume warfarin at a lower dose when the INR approaches the therapeutic range. Repeat INR; hold warfarin.
Major bleeding, any elevated INR: 2012 ACCP guidelines recommend prothrombin complex concentrate, human (PCC, Kcentra) plus vitamin K1 5-10 mg IV (dilute in 50 mL IV fluid and infuse over 20 min)…
Results: Intravenous vitamin K reduced INR more rapidly than oral vitamin K (5.09, 1.91, 1.54, and 1.41 vs 5.67, 2.90, 2.14, and 1.58) at baseline, 12, 24, and 48 hours, respectively. The dose of vitamin K (p . 0.001), route of administration (p 0.001), and baseline INR (p 0.001) influenced subsequent INR values. The INR reduction was similar for intravenous vitamin K doses 2 mg or greater.
10/1/2019 · The targeted INR range depends on indication for use and, at times, patient comorbidities. For most patients, vitamin K antagonists should be initiated at a maintenance dosage of 5 mg per day.
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While small studies have shown that a single low dose of oral vitamin K (1–2.5 mg) effectively reduces the INR in such patients within 24 hours, these studies have not been large enough to…
This recommendation is based on published studies on VKA overdoses, which show that a low dose of 0.5–2.5 mg of vitamin K can correct very high INR values (5–10), which increase the risk of.
Asymptomatic patients with an INR above 8.0 should have their warfarin dose omitted and be given 1mg of phytomenadione orally. If the INR is greatly above 8.0 (upwards of 10.0 for a patient with no risk factors for falls or haemorrhage), or the patient is elderly and at risk of.
Give Vitamin K 2 mg -4 mg orally (INR should be reduced within 24 hours). • If INR remains high, give an additional dose of Vitamin K 1 mg -2 mg orally. • Restart warfarin at lower dose once INR is within therapeutic range. Serious bleeding • See below, 1–5 mg, intravenous preparation to be used orally, dose to be given the day before surgery if INR ?1.5.
Vitamin D, Vitamin A, Vitamin C, Vitamin, Vitamin B12
