How does the estrogen receptor work? | Breast Cancer …
Types of Breast Cancer: Triple Negative, ER-Positive, HER2 …
How does the estrogen receptor work? | Breast Cancer …
Types of Breast Cancer: Triple Negative, ER-Positive, HER2 …
9/6/2018 · Estrogen receptor-positive (ER-positive) breast cancer is the most common type of breast cancer diagnosed today. According to the American Cancer Society, about 2.
Over half of all breast cancers overexpress ER alpha and around 70% of these respond to anti-estrogen (for example tamoxifen) therapy. In addition, the presence of elevated levels of ER alpha in benign breast epithelium appears to indicate an increased risk of breast cancer, suggesting a role for ER alpha in breast cancer initiation, as well as progression.
PDF | Background Breast cancer is the most common women malignancy worldwide, while estrogen receptor alpha positive type accounts for two third of all… | Find, read and cite all the research …
the transcriptomes of three estrogen receptor alpha positive (ER+) human breast cancer cell lines (MCF-7, T47D, ZR-75-1) and 13 human breast tumors (11 ER+; 2 ER-). Linear representations of the respective data structures were obtained by deriving those top principal.
ER? is a member of the nuclear receptor family, and its activity is implicated in the gene transcription linked to the proliferation of breast cancer cells, as well as in extranuclear signaling pathways related to the development of resistance to endocrine therapy.
4/1/2002 · Clinically, breast cancers have been classified as either ER-?-positive or ER-?-negative. While patients with ER-?-positive tumors have a slightly better survival rate than patients with ER-?-negative tumors, expression of ER-? is more useful as a predictive factor for response to endocrine therapy.
More recent studies have also shown that exposing ER-positive breast cancer cell lines to low oxygen levels, a common condition in vivo during breast cancer evolution, especially in certain lesions such as high-grade DCIS, can result in loss of ER through protein degradation, possibly mediated by upregulation of the transcription factor hypoxia-induced factor 1 alpha.
12/5/2008 · About 80% of all breast cancers are “ER-positive.” That means the cancer cells grow in response to the hormone estrogen. About 65% of these are also “PR-positive.” They grow in.
ER-positive: Breast cancers that have estrogen receptors are called ER-positive (or ER+) cancers. PR-positive : Breast cancers with progesterone receptors are called PR-positive (or PR+) cancers. Hormone receptor-positive : If the cancer cell has one or both of the receptors above, the term hormone-receptive positive (also called hormone-positive or HR+) breast cancer may be used.
