3/21/2017 · Myocardial Aging as a T-Cell–Mediated Phenomenon. Our data indicate that the myocardial and immunological aging processes are intertwined phenomena. It has been long recognized that myocardial aging is associated with increased interstitial fibrosis, hypertrophy, inflammation, stiffness, and mild contractile dysfunction .
3/21/2017 · A comprehensive characterization of different aged immune-deficient mouse strains revealed that T cells significantly contribute to age-related myocardial inflammation and functional decline. Upon adoptive cell transfer, the T cells isolated from the mediastinal lymph node (med-LN) of aged animals exhibited increased cardiotropism, compared with cells purified from young donors or from other.
Myocardial aging as a T-cell–mediated phenomenon Gustavo Campos Ramosa,b,1, Anne van den Berg b, Vânia Nunes-Silvac, Johannes Weirather , Laura Peters , Matthias Burkardb, Mike Friedrichd, Jürgen Pinnecker d, Marco Abeßere, Katrin G. Heinze , Kai Schuhe, Niklas Beyersdorf f, Thomas Kerkau , Jocelyne Demengeotc, Stefan Frantza,b,2, and Ulrich Hofmanna,b,2, Morphological, functional, and molecular analyses revealed that the age-related myocardial impairment occurs in parallel with shifts in the composition of tissue-resident leukocytes and with an…
In recent years, the myocardium has been rediscovered under the lenses of immunology, and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with different etiologies. Aging is an important risk factor for heart diseases, and it also has impact on the immune system. Thus, we sought to determine whether immunological activity would influence myocardial struc- ture and …
Myocardial aging as a T-cell–mediated phenomenon By Gustavo Campos Ramos, Anne van den Berg, Vânia Nunes-Silva, Johannes Weirather, Laura Peters, Matthias Burkard, Mike Friedrich, Jürgen Pinnecker, Marco Abeßer, Katrin G. Heinze, Kai Schuh, Niklas Beyersdorf, Thomas Kerkau, Demengeot Jocelyne, Stefan Frantz and Ulrich Hofmann, Beyond midlife, the immune system shows aging features and its defensive capability becomes impaired, by a process known as immunosenescence that involves many changes in the innate and adaptive responses. Innate immunity seems to be better preserved globally, while the adaptive immune response exhibits profound age-dependent modifications. Elderly people display a decline in numbers of naïve …
Myocardial aging as a T-cell–mediated phenomenon . Article. Full-text available. Mar 2017; Gustavo Campos Ramos. … Myocardial aging as a T-cell–mediated phenomenon . Citing article. Mar 2017;, Results. Aging was associated with a preservation of ventricular myocardial mass, aggregate number of mononucleated and binucleated myocytes, average cell diameter and volume in the female heart. In contrast, nearly 1 g/year of myocardium was lost in the male heart, and this phenomenon accounted for the loss of ?64 million cells.
Studying aging in humans is a difficult task. And this is because aging doesn’t occur alone, but rather, in concomitance to other risk factors which develop spontaneously, such as atherosclerosis. Thus, it becomes difficult to attribute the changes observed with aging to either aging …
